Recombinant Human TET1 protein (ab140810)
Key features and details
- Expression system: Baculovirus infected Sf9 cells
- Purity: > 90% Densitometry
- Suitable for: SDS-PAGE, WB
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Product name
Recombinant Human TET1 protein
See all TET1 proteins and peptides -
Purity
> 90 % Densitometry. -
Expression system
Baculovirus infected Sf9 cells -
Accession
-
Protein length
Protein fragment -
Animal free
No -
Nature
Recombinant -
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Species
Human -
Sequence
RFRIDPSSPLHEKNLEDNLQSLATRLAPIYKQYAPVAYQNQVEYENVARE CRLGSKEGRPFSGVTACLDFCAHPHRDIHNMNNGSTVVCTLTREDNRSLG VIPQDEQLHVLPLYKLSDTDEFGSKEGMEAKIKSGAIEVLAPRRKKRTCF TQPVPRSGKKRAAMMTEVLAHKIRAVEKKPIPRIKRKNNSTTTNNSKPSS LPTLGSNTETVQPEVKSETEPHFILKSSDNTKTYSLMPSAPHPVKEASPG FSWSPKTASATPAPLKNDATASCGFSERSSTPHCTMPSGRLSGANAAAAD GPGISQLGEVAPLPTLSAPVMEPLINSEPSTGVTEPLTPHQPNHQPSFLT SPQDLASSPMEEDEQHSEADEPPSDEPLSDDPLSPAEEKLPHIDEYWSDS EHIFLDANIGGVAIAPAHGSVLIECARRELHATTPVEHPNRNHPTRLSLV FYQHKNLNKPQHGFELNKIKFEAKEAKNKKMKASEQKDQAANEGPEQSSE VNELNQIPSHKALTLTHDNVVTVSPYALTHVAGPYNHWV -
Predicted molecular weight
110 kDa including tags -
Amino acids
1598 to 2136
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Preparation and Storage
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Alternative names
- bA119F7.1
- CXXC 6
- CXXC finger 6
see all -
Function
Dioxygenase that catalyzes the conversion of methylcytosine (5mC) to 5-hydroxymethylcytosine (hmC). Plays a role in embryonic stem (ES) cell maintenance and inner cell mass (ICM) cell specification, possibly by participating in DNA demethylation. Specifically binds 5mC, a minor base in mammalian DNA found in repetitive DNA elements that is crucial for retrotransposon silencing and mammalian development. 5mC is present in ES cells and is enriched in the brain, especially in Purkinje neurons. The clear function of hmC is still unclear but it could constitute an intermediate component in cytosine demethylation. A role of hmC in DNA demethylation is supported by TET1 function in ES cell maintenance, which is required to prevent NANOG hypermethylation and maintain NANOG expression in ES cells. -
Tissue specificity
Expressed in fetal heart, lung and brain, and in adult skeletal muscle, thymus and ovary. Not detected in adult heart, lung or brain. -
Involvement in disease
Note=A chromosomal aberration involving TET1 may be a cause of acute leukemias. Translocation t(10;11)(q22;q23) with MLL. This is a rare chromosomal translocation 5' MLL-TET1 3'. -
Sequence similarities
Belongs to the TET family.
Contains 1 CXXC-type zinc finger. -
Cellular localization
Nucleus. - Information by UniProt
Images
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SDS-PAGE - Recombinant Human TET1 protein (ab140810)SDS PAGE analysis of ab140810 at ~110 kDa.
