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Recombinant Human SLAM / CD150 protein (Tagged) (ab271409)

Key features and details

  • Expression system: HEK 293 cells
  • Purity: >= 90% SDS-PAGE
  • Tags: Avi tag C-Terminus, Fc tag C-Terminus
  • Suitable for: SDS-PAGE

Description

  • Product name

    Recombinant Human SLAM / CD150 protein (Tagged)
    See all SLAM / CD150 proteins and peptides

  • Purity

    >= 90 % SDS-PAGE.

  • Expression system

    HEK 293 cells

  • Accession

    Q13291

  • Protein length

    Protein fragment

  • Animal free

    No

  • Nature

    Recombinant

    • Species

      Human

    • Sequence

      ASYGTGGRMM NCPKILRQLG SKVLLPLTYE RINKSMNKSI HIVVTMAKSL ENSVENKIVS LDPSEAGPPR YLGDRYKFYL ENLTLGIRES RKEDEGWYLM TLEKNVSVQR FCLQLRLYEQ VSTPEIKVLN KTQENGTCTL ILGCTVEKGD HVAYSWSEKA GTHPLNPANS SHLLSLTLGP QHADNIYICT VSNPISNNSQ TFSPWPGCRT DPSETKP

    • Predicted molecular weight

      53 kDa including tags

    • Molecular weight information

      Protein runs at higher than predicted MW on SDS-PAGE due to glycosylation.

    • Amino acids

      21 to 237

    • Tags

      Avi tag C-Terminus , Fc tag C-Terminus

    • Additional sequence information

      Fc region of human IgG1. Genbank: NM_003037

Preparation and Storage

  • Alternative names

    • 4933415F16
    • AA177906
    • CD 150
    • CD150
    • CD150 antigen
    • CDw150
    • Estm51
    • Ipo 3
    • IPO-3
    • Ipo3
    • MGC151472
    • MGC151476
    • OTTHUMP00000025670
    • OTTHUMP00000060252
    • RGD1560634
    • Signaling lymphocytic activation molecule
    • Signaling lymphocytic activation molecule family member 1
    • Signaling lymphocytic activation molecule family member 1, isoform CRA_a
    • Signaling lymphocytic activation molecule family member 1, isoform CRA_b
    • Signaling lymphocytic activation molecule precursor
    • Slaf1
    • SLAF1_HUMAN
    • SLAM family, member 1
    • Slamf 1
    • SLAMF1
    • SLAMF1 protein
    see all

  • Function

    High-affinity self-ligand important in bidirectional T-cell to B-cell stimulation. SLAM-induced signal-transduction events in T-lymphocytes are different from those in B-cells. Two modes of SLAM signaling are likely to exist: one in which the inhibitor SH2D1A acts as a negative regulator and another in which protein-tyrosine phosphatase 2C (PTPN11)-dependent signal transduction operates.

  • Tissue specificity

    Constitutively expressed on peripheral blood memory T-cells, T-cell clones, immature thymocytes and a proportion of B-cells, and is rapidly induced on naive T-cells after activation.

  • Sequence similarities

    Contains 1 Ig-like C2-type (immunoglobulin-like) domain.
    Contains 1 Ig-like V-type (immunoglobulin-like) domain.

  • Domain

    The most membrane-proximal SH2-binding motif interacts with SH2 domain of SH2D1A and does not need to be phosphorylated on tyrosine residues.

  • Post-translational
    modifications

    Phosphorylated by FYN.

  • Cellular localization

    Cell membrane. Present on the surface of B-cells and T-cells.
  • Information by UniProt

Images

  • SDS-PAGE - Recombinant Human SLAM / CD150 protein (Tagged) (ab271409)
    SDS-PAGE - Recombinant Human SLAM / CD150 protein (Tagged) (ab271409)

    SDS-PAGE analysis of 4 μg of ab271409.

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