Antibodies, Proteins, Kits and Reagents for Life Science

Recombinant Human PRAME protein (ab181886)

Key features and details

Expression system: Escherichia coli
Purity: > 98% SDS-PAGE
Suitable for: Sandwich ELISA, SDS-PAGE, WB

Product name

Recombinant Human PRAME protein
See all PRAME proteins and peptides
Purity

> 98 % SDS-PAGE.
Expression system

Escherichia coli
Accession

P78395
Protein length

Protein fragment
Animal free

No
Nature

Recombinant
- Species
  
  Human
- Sequence
  
  MNPLETLSITNCRLSEGDVMHLSQSPSVSQLSVLSLSGVMLTDVSPEPLQ ALLERASATLQDLVFDECGITDDQLLALLPSLSHCSQLTTLSFYGNSISI
- Predicted molecular weight
  
  11 kDa
- Amino acids
  
  321 to 420

Alternative names
- 4930534P07Rik
- Cancer/testis antigen 130
- CT130
- MAPE
- Melanoma antigen preferentially expressed in tumors
- OIP 4
- OIP-4
- OIP4
- OPA interacting protein 4
- Opa interacting protein OIP4
- OPA-interacting protein 4
- PRAME
- PRAME_HUMAN
- Preferentially expressed antigen in melanoma
- Preferentially expressed antigen of melanoma
- RP23-250F8.3
see all
Function

Functions as a transcriptional repressor, inhibiting the signaling of retinoic acid through the retinoic acid receptors RARA, RARB and RARG. Prevents retinoic acid-induced cell proliferation arrest, differentiation and apoptosis.
Tissue specificity

Expressed in testis. Detected in samples of kidney, brain and skin.
Sequence similarities

Belongs to the PRAME family.
Contains 4 LRR (leucine-rich) repeats.
Cellular localization

Nucleus. Cell membrane.
Target information above from: UniProt accession P78395 The UniProt Consortium
The Universal Protein Resource (UniProt) in 2010
Nucleic Acids Res. 38:D142-D148 (2010) .

Information by UniProt

Sandwich ELISA - Recombinant Human PRAME protein (ab181886)

Sandwich ELISA using ab181886 as standard.
SDS-PAGE - Recombinant Human PRAME protein (ab181886)

15% SDS PAGE analysis of ab181886 under reducing conditions, stained with Coomassie blue.

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