Astana Biomed Group, an authorized Abcam distributor in Central Asia

Recombinant Human PD-L1 protein (Fc Chimera) (ab216252)

Key features and details

  • Expression system: CHO cells
  • Purity: >= 98% SDS-PAGE
  • Endotoxin level:
  • Suitable for: SDS-PAGE

Description

  • Product name

    Recombinant Human PD-L1 protein (Fc Chimera)
    See all PD-L1 proteins and peptides

  • Purity

    >= 98 % SDS-PAGE.

  • Endotoxin level

  • Expression system

    CHO cells

  • Accession

    Q9NZQ7

  • Protein length

    Protein fragment

  • Animal free

    No

  • Nature

    Recombinant

    • Species

      Human

    • Sequence

      FT VTVPKDLYVV EYGSNMTIEC KFPVEKQLDL AALIVYWEME DKNIIQFVHG EEDLKVQHSS YRQRARLLKD QLSLGNAALQ ITDVKLQDAG VYRCMISYGG ADYKRITVKV NAPYNKINQR ILVVDPVTSE HELTCQAEGY PKAEVIWTSS DHQVLSGKTT TTNSKREEKL FNVTSTLRIN TTTNEIFYCT FRRLDPEENH TAELVIPELP LAHPPNER

    • Predicted molecular weight

      25 kDa

    • Amino acids

      19 to 238

    • Additional sequence information

      Extracellular domain fused to the N-terminus of the Fc region of Human IgG1. (NP_054862.1).

    • Associated products

    Specifications

    Our Abpromise guarantee covers the use of ab216252 in the following tested applications.

    The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

    • Applications

      SDS-PAGE

    • Form

      Lyophilized
    • Concentration information loading...

    Preparation and Storage

    • Stability and Storage

      Shipped at 4°C. Store at -20°C long term. Avoid freeze / thaw cycle.

      Constituent: 100% PBS

    • Reconstitution
      Reconstitute with 100 µl sterile water. Add 1X PBS to the desired protein concentration.

    General Info

    • Alternative names

      • B7 H
      • B7 H1
      • B7 homolog 1
      • B7-H1
      • B7H
      • B7H1
      • CD 274
      • CD274
      • CD274 antigen
      • CD274 molecule
      • MGC142294
      • MGC142296
      • OTTHUMP00000021029
      • PD L1
      • PD-L1
      • PD1L1_HUMAN
      • PDCD1 ligand 1
      • PDCD1L1
      • PDCD1LG1
      • PDL 1
      • PDL1
      • Programmed cell death 1 ligand 1
      • Programmed death ligand 1
      • RGD1566211
      see all

    • Function

      Involved in the costimulatory signal, essential for T-cell proliferation and production of IL10 and IFNG, in an IL2-dependent and a PDCD1-independent manner. Interaction with PDCD1 inhibits T-cell proliferation and cytokine production.

    • Tissue specificity

      Highly expressed in the heart, skeletal muscle, placenta and lung. Weakly expressed in the thymus, spleen, kidney and liver. Expressed on activated T- and B-cells, dendritic cells, keratinocytes and monocytes.

    • Sequence similarities

      Belongs to the immunoglobulin superfamily. BTN/MOG family.
      Contains 1 Ig-like C2-type (immunoglobulin-like) domain.
      Contains 1 Ig-like V-type (immunoglobulin-like) domain.

    • Cellular localization

      Cell membrane and Endomembrane system.
    • Information by UniProt

Protocols

To our knowledge, customised protocols are not required for this product. Please try the standard protocols listed below and let us know how you get on.

Click here to view the general protocols

References (0)

Publishing research using ab216252? Please let us know so that we can cite the reference in this datasheet.

ab216252 has not yet been referenced specifically in any publications.

Preparation and Storage

  • Stability and Storage

    Shipped at 4°C. Store at -20°C long term. Avoid freeze / thaw cycle.

    Constituent: 100% PBS

  • Reconstitution
    Reconstitute with 100 µl sterile water. Add 1X PBS to the desired protein concentration.

Images

Please note: All products are "FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC PROCEDURES"
For licensing inquiries, please contact partnerships@abcam.com

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