Recombinant Human MICA protein (Tagged) (ab271612)
Key features and details
- Expression system: HEK 293 cells
- Purity: >= 90% SDS-PAGE
- Tags: Avi tag C-Terminus, Fc tag C-Terminus
- Suitable for: SDS-PAGE
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Product name
Recombinant Human MICA protein (Tagged) -
Purity
>= 90 % SDS-PAGE. -
Expression system
HEK 293 cells -
Accession
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Protein length
Protein fragment -
Animal free
No -
Nature
Recombinant -
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Species
Human -
Sequence
AEPHSLRY NLTVLSWDGS VQSGFLAEVH LDGQPFLRYD RQKCRAKPQG QWAEDVLGNK TWDRETRDLT GNGKDLRMTL AHIKDQKEGL HSLQEIRVCE IHEDNSTRSS QHFYYDGELF LSQNLETEEW TVPQSSRAQT LAMNVRNFLK EDAMKTKTHY HAMHADCLQE LRRYLESGVV LRRTVPPMVN VTRSEASEGN ITVTCRASSF YPRNIILTWR QDGVSLSHDT QQWGDVLPDG NGTYQTWVAT RICRGEEQRF TCYMEHSGNH STHPVPSGKV LVLQSHWQ -
Predicted molecular weight
62 kDa -
Amino acids
23 to 308 -
Tags
Avi tag C-Terminus , Fc tag C-Terminus -
Additional sequence information
Fc portion of human IgG1.
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Preparation and Storage
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Alternative names
- FLJ60820
- HLA class I antigen
- MGC111087
see all -
Relevance
The MHC class I chain-related (MIC) proteins are related to the Major histocompatibility complex (MHC) class I proteins which are ubiquitously expressed and mediate the recognition of intracellular antigens by cytotoxic T cells. The MHC class I chain-related (MIC) proteins are recognized by NKG2D, a receptor on NK and T cells, and promote anti-tumor activity. MICA, a member of the MIC family, is widely expressed on many tumors, and it is the MICA/NKG2D interaction that is thought to stimulate the anti-tumor reactivity by T lymphocytes. MICA is present in virtually every tissue except the nervous system, suggesting that MIC protein expression may only be one component of the anti-tumor activity of the immune system. -
Cellular localization
Plasma membrane
Images
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SDS-PAGE - Recombinant Human MICA protein (Tagged) (ab271612)
SDS-PAGE analysis of 4 µg ab271612.