Recombinant human Leptin protein (ab119739)
Key features and details
- Expression system: Escherichia coli
- Active: Yes
- Suitable for: Functional Studies
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Product name
Recombinant human Leptin protein
See all Leptin proteins and peptides -
Biological activity
Biological Activity is evidenced by high affinity binding of mammalian leptins at 1:1 molar ratio -
Expression system
Escherichia coli -
Accession
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Protein length
Protein fragment -
Animal free
No -
Nature
Recombinant -
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Species
Human -
Sequence
The sequence of the first four N-terminal amino acids was determined and was found to be Ala-Thr-Pro-Val. -
Predicted molecular weight
25 kDa -
Amino acids
428 to 635
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Preparation and Storage
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Alternative names
- FLJ94114
- LEP
- LEP_HUMAN
see all -
Function
May function as part of a signaling pathway that acts to regulate the size of the body fat depot. An increase in the level of LEP may act directly or indirectly on the CNS to inhibit food intake and/or regulate energy expenditure as part of a homeostatic mechanism to maintain constancy of the adipose mass. -
Involvement in disease
Defects in LEP may be a cause of obesity (OBESITY) [MIM:601665]. It is a condition characterized by an increase of body weight beyond the limitation of skeletal and physical requirements, as the result of excessive accumulation of body fat. -
Sequence similarities
Belongs to the leptin family. -
Cellular localization
Secreted. - Information by UniProt
