Astana Biomed Group, an authorized Abcam distributor in Central Asia

Recombinant human LEC protein (ab627)

Key features and details

  • Expression system: Escherichia coli
  • Endotoxin level:
  • Active: Yes
  • Suitable for: Functional Studies, SDS-PAGE

Description

  • Product name

    Recombinant human LEC protein
    See all LEC proteins and peptides

  • Endotoxin level

  • Expression system

    Escherichia coli

  • Protein length

    Full length protein

  • Animal free

    No

  • Nature

    Recombinant

    • Species

      Human

    • Sequence

      hLEC is an 11.2 kDa protein containing 97 amino acid residues: QPKVPEWVNT PSTCCLKYYE KVLPRRLVVG YRKA LNCHLP AIIFVTKRNR EVCTNPNDDWVQEYIKDPNL PLLPTRNLST VKIITAKNGQ PQLLNSQ

    • Associated products

      Specifications

      Our Abpromise guarantee covers the use of ab627 in the following tested applications.

      The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

      • Applications

        Functional Studies

        SDS-PAGE

      • Form

        Lyophilized

      • Additional notes

        The biological activity of this product is determined by its ability to chemoattract human monocytes using a concentration range of 10.0-100.0 ng/ml.
      • Concentration information loading...

      Preparation and Storage

      • Stability and Storage

        Shipped at 4°C. Store at +4°C short term (1-2 weeks). Upon delivery aliquot. Store at -20°C or -80°C. Avoid freeze / thaw cycle.

        This product is an active protein and may elicit a biological response in vivo, handle with caution.

      • Reconstitution
        For lot specific reconstitution information please contact our Scientific Support Team.

      General Info

      • Alternative names

        • C-C motif chemokine 16
        • CCL16
        • CCL16_HUMAN
        • Chemokine (C-C motif) ligand 16
        • Chemokine CC-4
        • Chemokine LEC
        • CKb12
        • HCC-4
        • HCC4
        • IL-10-inducible chemokine
        • IL10 inducible chemokine
        • ILINCK
        • LCC-1
        • LCC1
        • Liver CC chemokine 1 precursor
        • Liver expressed chemokine
        • Liver-expressed chemokine
        • LMC
        • Lymphocyte and monocyte chemoattractant
        • Monotactin 1
        • Monotactin-1
        • MTN-1
        • Mtn1
        • NCC-4
        • NCC4
        • New CC chemokine 4
        • SCYA16
        • SCYL4
        • Small inducible cytokine A16 precursor
        • Small inducible cytokine subfamily A (Cys Cys) member 16
        • Small-inducible cytokine A16
        see all

      • Function

        Shows chemotactic activity for lymphocytes and monocytes but not neutrophils. Also shows potent myelosuppressive activity, suppresses proliferation of myeloid progenitor cells. Recombinant SCYA16 shows chemotactic activity for monocytes and THP-1 monocytes, but not for resting lymphocytes and neutrophils. Induces a calcium flux in THP-1 cells that were desensitized by prior expression to RANTES.

      • Tissue specificity

        Mainly expressed in liver, also found in spleen and thymus. Highly expressed in LPS- and IFN-gamma-activated monocytes, weakly in some lymphocytes, including natural killer cells, gamma-delta T-cells, and some T-cell clones.

      • Sequence similarities

        Belongs to the intercrine beta (chemokine CC) family.

      • Cellular localization

        Secreted.
      • Information by UniProt

    Protocols

    To our knowledge, customised protocols are not required for this product. Please try the standard protocols listed below and let us know how you get on.

    Click here to view the general protocols

    References (0)

    Publishing research using ab627? Please let us know so that we can cite the reference in this datasheet.

    ab627 has not yet been referenced specifically in any publications.

    Preparation and Storage

    • Alternative names

      • C-C motif chemokine 16
      • CCL16
      • CCL16_HUMAN
      • Chemokine (C-C motif) ligand 16
      • Chemokine CC-4
      • Chemokine LEC
      • CKb12
      • HCC-4
      • HCC4
      • IL-10-inducible chemokine
      • IL10 inducible chemokine
      • ILINCK
      • LCC-1
      • LCC1
      • Liver CC chemokine 1 precursor
      • Liver expressed chemokine
      • Liver-expressed chemokine
      • LMC
      • Lymphocyte and monocyte chemoattractant
      • Monotactin 1
      • Monotactin-1
      • MTN-1
      • Mtn1
      • NCC-4
      • NCC4
      • New CC chemokine 4
      • SCYA16
      • SCYL4
      • Small inducible cytokine A16 precursor
      • Small inducible cytokine subfamily A (Cys Cys) member 16
      • Small-inducible cytokine A16
      see all

    • Function

      Shows chemotactic activity for lymphocytes and monocytes but not neutrophils. Also shows potent myelosuppressive activity, suppresses proliferation of myeloid progenitor cells. Recombinant SCYA16 shows chemotactic activity for monocytes and THP-1 monocytes, but not for resting lymphocytes and neutrophils. Induces a calcium flux in THP-1 cells that were desensitized by prior expression to RANTES.

    • Tissue specificity

      Mainly expressed in liver, also found in spleen and thymus. Highly expressed in LPS- and IFN-gamma-activated monocytes, weakly in some lymphocytes, including natural killer cells, gamma-delta T-cells, and some T-cell clones.

    • Sequence similarities

      Belongs to the intercrine beta (chemokine CC) family.

    • Cellular localization

      Secreted.
    • Information by UniProt

    Images

    Please note: All products are "FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC PROCEDURES"
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