Astana Biomed Group, an authorized Abcam distributor in Central Asia

Recombinant Human Granulin protein (ab108947)

Key features and details

  • Expression system: Escherichia coli
  • Purity: > 90% SDS-PAGE
  • Endotoxin level:
  • Tags: His tag N-Terminus
  • Suitable for: SDS-PAGE

Description

  • Product name

    Recombinant Human Granulin protein
    See all Granulin proteins and peptides

  • Purity

    > 90 % SDS-PAGE.
    ab108947 is 0.2µm filtered.

  • Endotoxin level

  • Expression system

    Escherichia coli

  • Accession

    P28799

  • Protein length

    Full length protein

  • Animal free

    No

  • Nature

    Recombinant

    • Species

      Human

    • Predicted molecular weight

      10 kDa including tags

    • Amino acids

      364 to 430

    • Tags

      His tag N-Terminus

    • Specifications

    Our Abpromise guarantee covers the use of ab108947 in the following tested applications.

    The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

    • Applications

      SDS-PAGE

    • Form

      Liquid
    • Concentration information loading...

    Preparation and Storage

    • Stability and Storage

      Shipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid freeze / thaw cycles.

      pH: 8.20
      Constituents: 0.869% Tris HCl, 0.87% Sodium chloride

    General Info

    • Alternative names

      • Acrogranin
      • CLN11
      • GEP
      • GP88
      • Granulin A
      • Granulin B
      • Granulin C
      • Granulin D
      • Granulin E
      • Granulin epithelin
      • Granulin F
      • Granulin G
      • Granulin-7
      • Granulins
      • GRN
      • GRN_HUMAN
      • PC cell derived growth factor
      • PCDGF
      • PEPI
      • PGRN
      • Proepithelin
      • Progranulin
      see all

    • Function

      Granulins have possible cytokine-like activity. They may play a role in inflammation, wound repair, and tissue remodeling.
      Granulin-4 promotes proliferation of the epithelial cell line A431 in culture while granulin-3 acts as an antagonist to granulin-4, inhibiting the growth.

    • Tissue specificity

      In myelogenous leukemic cell lines of promonocytic, promyelocytic, and proerythroid lineage, in fibroblasts, and very strongly in epithelial cell lines. Present in inflammatory cells and bone marrow. Highest levels in kidney.

    • Involvement in disease

      Defects in GRN are the cause of ubiquitin-positive frontotemporal dementia (UP-FTD) [MIM:607485]; also known as tau-negative frontotemporal dementia linked to chromosome 17. Frontotemporal dementia (FTD) is the second most common cause of dementia in people under the age of 65 years. It is an autosomal dominant neurodegenerative disease.

    • Sequence similarities

      Belongs to the granulin family.

    • Post-translational
      modifications

      Granulins are disulfide bridged.

    • Cellular localization

      Secreted.
    • Information by UniProt

Protocols

To our knowledge, customised protocols are not required for this product. Please try the standard protocols listed below and let us know how you get on.

Click here to view the general protocols

References (0)

Publishing research using ab108947? Please let us know so that we can cite the reference in this datasheet.

ab108947 has not yet been referenced specifically in any publications.

Preparation and Storage

  • Stability and Storage

    Shipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid freeze / thaw cycles.

    pH: 8.20
    Constituents: 0.869% Tris HCl, 0.87% Sodium chloride

Images

Please note: All products are "FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC PROCEDURES"
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