Astana Biomed Group, an authorized Abcam distributor in Central Asia

Recombinant Human GAMT protein (ab185414)

Key features and details

  • Expression system: Escherichia coli
  • Purity: > 95% SDS-PAGE
  • Endotoxin level:
  • Tags: His tag C-Terminus, His tag N-Terminus
  • Suitable for: SDS-PAGE, HPLC

Description

  • Product name

    Recombinant Human GAMT protein
    See all GAMT proteins and peptides

  • Purity

    > 95 % SDS-PAGE.
    Purity is determined by SEC-HPLC and reducing SDS-PAGE.

  • Endotoxin level

  • Expression system

    Escherichia coli

  • Accession

    Q14353

  • Protein length

    Full length protein

  • Animal free

    No

  • Nature

    Recombinant

    • Species

      Human

    • Sequence

      MGSSHHHHHHSSGLVPRGSHMSAPSATPIFAPGENCSPAWGAAPAAYDAA DTHLRILGKPVMERWETPYMHALAAAASSKGGRVLEVGFGMAIAASKVQE APIDEHWIIECNDGVFQRLRDWAPRQTHKVIPLKGLWEDVAPTLPDGHFD GILYDTYPLSEETWHTHQFNFIKNHAFRLLKPGGVLTYCNLTSWGELMKS KYSDITIMFEETQVPALLEAGFRRENIRTEVMALVPPADCRYYAFPQMIT PLVTKGLEHH HHHH

    • Predicted molecular weight

      30 kDa including tags

    • Amino acids

      1 to 236

    • Tags

      His tag C-Terminus , His tag N-Terminus

    • Specifications

    Our Abpromise guarantee covers the use of ab185414 in the following tested applications.

    The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

    • Applications

      SDS-PAGE

      HPLC

    • Form

      Liquid
    • Concentration information loading...

    Preparation and Storage

    • Stability and Storage

      Shipped on Dry Ice. Upon delivery aliquot. Store at -20°C. Avoid freeze / thaw cycle.

      pH: 8.00
      Constituents: 0.32% Tris HCl, 0.02% DTT

    General Info

    • Alternative names

      • CCDS2
      • Epididymis secretory protein Li 20
      • GAMT
      • GAMT_HUMAN
      • Guanidinoacetate N methyltransferase
      • Guanidinoacetate N-methyltransferase
      • HEL-S-20
      • PIG2
      • TP53I2
      see all

    • Tissue specificity

      Expressed in liver.

    • Pathway

      Amine and polyamine biosynthesis; creatine biosynthesis; creatine from L-arginine and glycine: step 2/2.

    • Involvement in disease

      Defects in GAMT are the cause of guanidinoacetate methyltransferase deficiency (GAMT deficiency) [MIM:612736]. GAMT deficiency is an autosomal recessive disorder characterized by developmental delay/regression, mental retardation, severe disturbance of expressive and cognitive speech, intractable seizures and movement disturbances, severe depletion of creatine/phosphocreatine in the brain, and accumulation of guanidinoacetic acid (GAA) in brain and body fluids.

    • Sequence similarities

      Belongs to the RMT2 methyltransferase family.
    • Information by UniProt

Protocols

To our knowledge, customised protocols are not required for this product. Please try the standard protocols listed below and let us know how you get on.

Click here to view the general protocols

References (0)

Publishing research using ab185414? Please let us know so that we can cite the reference in this datasheet.

ab185414 has not yet been referenced specifically in any publications.

Preparation and Storage

  • Stability and Storage

    Shipped on Dry Ice. Upon delivery aliquot. Store at -20°C. Avoid freeze / thaw cycle.

    pH: 8.00
    Constituents: 0.32% Tris HCl, 0.02% DTT

Images

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