Recombinant Human DLL1 protein (ab108952)
Key features and details
- Expression system: CHO cells
- Purity: > 90% SDS-PAGE
- Endotoxin level:
- Tags: Fc tag C-Terminus
- Suitable for: Functional Studies, SDS-PAGE
Preparation and Storage
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Alternative names
- Delta
- Delta (Drosophila) like 1
- Delta like 1
see all -
Function
Acts as a ligand for Notch receptors. Blocks the differentiation of progenitor cells into the B-cell lineage while promoting the emergence of a population of cells with the characteristics of a T-cell/NK-cell precursor. -
Tissue specificity
Expressed in heart and pancreas, with lower expression in brain and muscle and almost no expression in placenta, lung, liver and kidney. -
Sequence similarities
Contains 1 DSL domain.
Contains 8 EGF-like domains. -
Post-translational
modificationsUbiquitinated by MIB (MIB1 or MIB2), leading to its endocytosis and subsequent degradation. -
Cellular localization
Membrane. - Information by UniProt
Images
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Functional Studies - Recombinant Human DLL1 protein (ab108952)Induction of Hes1 with the treatment of ab108952.
A mouse preadpipocyte cell line, 3T3L1, was stimulated with 5ug/ml of ab108952 as in indicated time points and each cell lysate was prepared and subjected to western blot by using anti-Mouse Hes1 or GAPDH. -
Functional Studies - Recombinant Human DLL1 protein (ab108952)Interaction of Human Notch1 with Human DLL1. HEK293 cells transfected with a human Notch1 or a Human GITR ligand expressing vector were incubated with 25 ug/ml of Human GITR-Fc or ab108952). Cells were stained with anti-Human IgG(Fc specific) FITC conjugate for DLL1-Fc binding.
