Antibodies, Proteins, Kits and Reagents for Life Science

Key features and details

Expression system: HEK 293 cells
Purity: > 95% SDS-PAGE
Endotoxin level:
Tags: Fc tag C-Terminus
Suitable for: SDS-PAGE, HPLC

Alternative names
- 3CH61
- CCN 1
- CCN family member 1
- CCN1
- CYR 61
- Cyr61
- CYR61 protein
- CYR61_HUMAN
- Cysteine rich angiogenic inducer 61
- Cysteine rich heparin binding protein 61
- Cysteine-rich angiogenic inducer 61
- GIG 1
- GIG1
- IBP-10
- IGF-binding protein 10
- Igfbp 10
- IGFBP-10
- Igfbp10
- Insulin like growth factor binding protein 10
- Insulin-like growth factor-binding protein 10
- Protein CYR61
- Protein GIG1
see all
Function

Promotes cell proliferation, chemotaxis, angiogenesis and cell adhesion. Appears to play a role in wound healing by up-regulating, in skin fibroblasts, the expression of a number of genes involved in angiogenesis, inflammation and matrix remodeling including VEGA-A, VEGA-C, MMP1, MMP3, TIMP1, uPA, PAI-1 and integrins alpha-3 and alpha-5. CYR61-mediated gene regulation is dependent on heparin-binding. Down-regulates the expression of alpha-1 and alpha-2 subunits of collagen type-1. Promotes cell adhesion and adhesive signaling through integrin alpha-6/beta-1, cell migration through integrin alpha-v/beta-5 and cell proliferation through integrin alpha-v/beta-3.
Sequence similarities

Belongs to the CCN family.
Contains 1 CTCK (C-terminal cystine knot-like) domain.
Contains 1 IGFBP N-terminal domain.
Contains 1 TSP type-1 domain.
Contains 1 VWFC domain.
Cellular localization

Secreted.
Target information above from: UniProt accession O00622 The UniProt Consortium
The Universal Protein Resource (UniProt) in 2010
Nucleic Acids Res. 38:D142-D148 (2010) .

Information by UniProt

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