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Recombinant human CYR61/CCN1 protein (Active) (ab50074)

Key features and details

  • Expression system: Escherichia coli
  • Purity: > 95% SDS-PAGE
  • Active: Yes
  • Suitable for: SDS-PAGE, Functional Studies

Description

  • Product name

    Recombinant human CYR61/CCN1 protein (Active)
    See all CYR61/CCN1 proteins and peptides

  • Biological activity

    Determined by the dose-dependent stimulation of the proliferation of murine 3T3 cells. The expected ED50 for this effect is 2.0-3.0 μg/ml.

  • Purity

    > 95 % SDS-PAGE.
    ab50074 purity was estimated also by HPLC.

  • Expression system

    Escherichia coli

  • Accession

    O00622

  • Protein length

    Protein fragment

  • Animal free

    No

  • Nature

    Recombinant

    • Species

      Human

    • Sequence

      TCPAACHCP LEAPKCAPGV GLVRDGCGCC KVCAKQLNED CSKTQPCDHT KGLECNFGAS STALKGICRA QSEGRPCEYN SRIYQNGESF QPNCKHQCTC IDGAVGCIPL CPQELSLPNL GCPNPRLVKV TGQCCEEWVC DEDSIKDPME DQDGLLGKEL GFDASEVELT RNNELIAVGK GSSLKRLPVF GMEPRILYNP LQGQKCIVQT TSWSQCSKTC GTGISTRVTN DNPECRLVKE TRICEVRPCG QPVYSSLKKG KKCSKTKKSP EPVRFTYAGC LSVKKYRPKY CGSCVDGRCC TPQLTRTVKM RFRCEDGETF SKNVMMIQSC KCNYNCPHAN EAAFPFYRLF NDIHKFRD

    • Predicted molecular weight

      40 kDa

    • Amino acids

      25 to 381

Preparation and Storage

  • Alternative names

    • 3CH61
    • CCN 1
    • CCN family member 1
    • CCN1
    • CYR 61
    • Cyr61
    • CYR61 protein
    • CYR61_HUMAN
    • Cysteine rich angiogenic inducer 61
    • Cysteine rich heparin binding protein 61
    • Cysteine-rich angiogenic inducer 61
    • GIG 1
    • GIG1
    • IBP-10
    • IGF-binding protein 10
    • Igfbp 10
    • IGFBP-10
    • Igfbp10
    • Insulin like growth factor binding protein 10
    • Insulin-like growth factor-binding protein 10
    • Protein CYR61
    • Protein GIG1
    see all

  • Function

    Promotes cell proliferation, chemotaxis, angiogenesis and cell adhesion. Appears to play a role in wound healing by up-regulating, in skin fibroblasts, the expression of a number of genes involved in angiogenesis, inflammation and matrix remodeling including VEGA-A, VEGA-C, MMP1, MMP3, TIMP1, uPA, PAI-1 and integrins alpha-3 and alpha-5. CYR61-mediated gene regulation is dependent on heparin-binding. Down-regulates the expression of alpha-1 and alpha-2 subunits of collagen type-1. Promotes cell adhesion and adhesive signaling through integrin alpha-6/beta-1, cell migration through integrin alpha-v/beta-5 and cell proliferation through integrin alpha-v/beta-3.

  • Sequence similarities

    Belongs to the CCN family.
    Contains 1 CTCK (C-terminal cystine knot-like) domain.
    Contains 1 IGFBP N-terminal domain.
    Contains 1 TSP type-1 domain.
    Contains 1 VWFC domain.

  • Cellular localization

    Secreted.
  • Information by UniProt

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