Recombinant Human beta-cardiac myosin heavy chain protein (ab112326)
Key features and details
- Expression system: Wheat germ
- Tags: GST tag N-Terminus
- Suitable for: ELISA, WB, SDS-PAGE
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Product name
Recombinant Human beta-cardiac myosin heavy chain protein -
Expression system
Wheat germ -
Accession
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Protein length
Protein fragment -
Animal free
No -
Nature
Recombinant -
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Species
Human -
Sequence
MGDSEMAVFGAAAPYLRKSEKERLEAQTRPFDLKKDVFVPDDKQEFVKAK IVSREGGKVTAETEYGKTVTVKEDQVMQQNPPKFDKIEDMAMLTFLHEPA VLYNLKDRY -
Predicted molecular weight
38 kDa including tags -
Amino acids
1 to 109 -
Tags
GST tag N-Terminus
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Preparation and Storage
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Alternative names
- cardiomyopathy, hypertrophic 1
- CMD1S
- CMH1
see all -
Relevance
Muscle myosin is a hexameric protein that consists of 2 heavy chain subunits (MHC), 2 alkali light chain subunits (MLC) and 2 regulatory light chain subunits (MLC-2). Cardiac MHC exists as two isoforms in humans, alpha-cardiac MHC and beta-cardiac MHC. These two isoforms are expressed in different amounts in the human heart. During normal physiology, beta-cardiac MHC is the predominant form, with the alpha-isoform contributing around only 7% of the total MHC. Mutations of the MHC genes are associated with several different dilated and hypertrophic cardiomyopathies. -
Cellular localization
Thick filaments of the myofibrils.
Images
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SDS-PAGE - Recombinant Human beta-cardiac myosin heavy chain protein (ab112326)ab112326 analysed on a 12.5% SDS-PAGE gel stained with Coomassie Blue.