Recombinant Human BAFF-R protein (Tagged) (ab271388)
Key features and details
- Expression system: HEK 293 cells
- Purity: >= 90% SDS-PAGE
- Tags: Avi tag C-Terminus, Fc tag C-Terminus
- Suitable for: SDS-PAGE
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Product name
Recombinant Human BAFF-R protein (Tagged)
See all BAFF-R proteins and peptides -
Purity
>= 90 % SDS-PAGE. -
Expression system
HEK 293 cells -
Accession
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Protein length
Protein fragment -
Animal free
No -
Nature
Recombinant -
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Species
Human -
Sequence
ECFDLLVRHC VACGLLRTPR PKPAGASSPA PRTALQPQES VGAGAGEAA -
Predicted molecular weight
34 kDa including tags -
Amino acids
23 to 71 -
Tags
Avi tag C-Terminus , Fc tag C-Terminus -
Additional sequence information
Fused at the C terminus to the Fc portion of human IgG1 followed by a C-terminal Avi™-tag.
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Preparation and Storage
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Alternative names
- B cell activating factor receptor
- B-cell-activating factor receptor
- BAFF R
see all -
Function
B-cell receptor specific for TNFSF13B/TALL1/BAFF/BLyS. Promotes the survival of mature B-cells and the B-cell response. -
Tissue specificity
Highly expressed in spleen and lymph node, and in resting B-cells. Detected at lower levels in activated B-cells, resting CD4+ T-cells, in thymus and peripheral blood leukocytes. -
Involvement in disease
Defects in TNFRSF13C are the cause of immunodeficiency common variable type 4 (CVID4) [MIM:613494]; also called antibody deficiency due to BAFFR defect. CVID4 is a primary immunodeficiency characterized by antibody deficiency, hypogammaglobulinemia, recurrent bacterial infections and an inability to mount an antibody response to antigen. The defect results from a failure of B-cell differentiation and impaired secretion of immunoglobulins; the numbers of circulating B cells is usually in the normal range, but can be low. -
Sequence similarities
Contains 1 TNFR-Cys repeat. -
Cellular localization
Membrane. - Information by UniProt
Images
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SDS-PAGE - Recombinant Human BAFF-R protein (Tagged) (ab271388)
SDS-PAGE analysis of 4 µg ab271388.