Recombinant human APRIL/TNFSF13 protein (Active) (ab243049)
Key features and details
- Expression system: HEK 293 cells
- Purity: > 95% SDS-PAGE
- Endotoxin level:
- Active: Yes
- Tags: Fc tag N-Terminus
- Suitable for: Functional Studies, SDS-PAGE
Preparation and Storage
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Alternative names
- A proliferation inducing ligand
- A proliferation-inducing ligand
- APRIL
see all -
Function
Cytokine that binds to TNFRSF13B/TACI and to TNFRSF17/BCMA. May be implicated in the regulation of tumor cell growth. May be involved in monocyte/macrophage-mediated immunological processes. -
Tissue specificity
Expressed at high levels in transformed cell lines, cancers of colon, thyroid, lymphoid tissues and specifically expressed in monocytes and macrophages. -
Sequence similarities
Belongs to the tumor necrosis factor family. -
Post-translational
modificationsThe precursor is cleaved by furin. -
Cellular localization
Secreted. - Information by UniProt
Images
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Functional Studies - Recombinant human APRIL/TNFSF13 protein (Active) (ab243049)
ab243049 at 5 μg/mL (100 μL/well) can bind Biotinylated Human TACI, Fc Tag, Avi Tag with a linear range of 0.01-0.313 μg/mL.
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Functional Studies - Recombinant human APRIL/TNFSF13 protein (Active) (ab243049)Immobilized Human BCMA, Mouse IgG2a Fc Tag, low endotoxin at 5 μg/mL (100 μL/well) can bind ab243049 with a linear range of 0.6-10 ng/mL.
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SDS-PAGE - Recombinant human APRIL/TNFSF13 protein (Active) (ab243049)SDS-PAGE analysis of ab 243049 under reducing (R) condition.
The gel was stained overnight with Coomassie Blue.
The purity of the protein is greater than 95%.
The protein migrates as 48 kDa under reducing (R) condition (SDS-PAGE) due to glycosylation.
