Recombinant Human 14-3-3 Tau protein (ab70352)
Key features and details
- Expression system: Escherichia coli
- Purity: > 95% SDS-PAGE
- Tags: GST tag N-Terminus
- Suitable for: WB
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Product name
Recombinant Human 14-3-3 Tau protein
See all 14-3-3 Tau proteins and peptides -
Purity
> 95 % SDS-PAGE.
The purity was determined to be >95% by densitometry. -
Expression system
Escherichia coli -
Accession
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Protein length
Full length protein -
Animal free
No -
Nature
Recombinant -
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Species
Human -
Tags
GST tag N-Terminus
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Preparation and Storage
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Alternative names
- 14 3 3 protein T cell
- 14 3 3 protein tau
- 14 3 3 protein theta
see all -
Function
Adapter protein implicated in the regulation of a large spectrum of both general and specialized signaling pathways. Binds to a large number of partners, usually by recognition of a phosphoserine or phosphothreonine motif. Binding generally results in the modulation of the activity of the binding partner. Negatively regulates the kinase activity of PDPK1. -
Tissue specificity
Abundantly expressed in brain, heart and pancreas, and at lower levels in kidney and placenta. Up-regulated in the lumbar spinal cord from patients with sporadic amyotrophic lateral sclerosis (ALS) compared with controls, with highest levels of expression in individuals with predominant lower motor neuron involvement. -
Sequence similarities
Belongs to the 14-3-3 family. -
Post-translational
modificationsSer-232 is probably phosphorylated by CK1. -
Cellular localization
Cytoplasm. In neurons, axonally transported to the nerve terminals. - Information by UniProt
Images
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SDS-PAGE - Recombinant Human 14-3-3 Tau protein (ab70352)SDS-PAGE showing ab70532 14-3-3 Tau protein at approximately 56kDa.
