Recombinant HIV1 gp41 protein (ab49070)
Key features and details
- Expression system: Escherichia coli
- Suitable for: ELISA, WB
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Product name
Recombinant HIV1 gp41 protein
See all HIV1 gp41 proteins and peptides -
Expression system
Escherichia coli -
Protein length
Full length protein -
Animal free
No -
Nature
Recombinant
Preparation and Storage
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Alternative names
- Env
- Glycoprotein 41
- gp41
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Relevance
gp41/120 is the major HIV protein associated with the HIV envelope. It functions as the viral antireceptor or attachment protein. gp41 (or TM) traverses the envelope, whereas gp120 is present on the outer surface and is noncovalently attached to gp41. The precursor of gp120/41 (gp160) is synthesized in the endoplasmic reticulum and is transported via the golgi body to the cell surface. Upon activation of the envelope glycoprotein (gp120/41) by cellular receptors, gp41 undergoes conformational changes that mediate fusion of the viral and cellular membranes.
Images
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ELISA - Recombinant HIV1 gp41 protein (ab49070)
ELISA using ab49070 at 2µg/mL Antibodies which recognise the 2F5 and 4E10 epitope were used as primary antibodies, and Protein A HRP was used as a seconday antibody.
Significance: gp41-specific antibodies which bind two different epitopes are able to recognize this full length gp41 in ELISA