(R)-Flurbiprofen (Tarenflurbil), gamma-secretase inhibitor (ab144471)
Key features and details
- γ-secretase inhibitor
- CAS Number: 51543-40-9
- Purity: > 99%
- Soluble in ethanol to 100 mM and in DMSO to 25 mM
- Form / State: Solid
- Source: Synthetic
Overview
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Product name
(R)-Flurbiprofen (Tarenflurbil), gamma-secretase inhibitor -
Description
γ-secretase inhibitor -
Alternative names
- Tarenflurbil
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Biological description
γ-secretase inhibitor. Flurbiprofen (ab142877) enantiomer. Inactive towards COX. Inhibits NF-κB and AP-1 activation. Prevents Aβ42 formation and shows anti-inflammatory and neuroprotective effects in vivo. Orally active. -
Purity
> 99% -
CAS Number
51543-40-9 -
Chemical structure
Properties
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Chemical name
(2R)-2-(3-Fluoro-4-phenylphenyl)propanoic acid -
Molecular weight
244.26 -
Molecular formula
C15H13FO2 -
PubChem identifier
92337 -
Storage instructions
Store at -20°C. Store under desiccating conditions. The product can be stored for up to 12 months. -
Solubility overview
Soluble in ethanol to 100 mM and in DMSO to 25 mM -
Handling
Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.
Toxic, refer to SDS for further information.
Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.
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SMILES
C[C@H](C1=CC(=C(C=C1)C2=CC=CC=C2)F)C(=O)O -
Source
Synthetic
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Research areas
- Biochemicals
- Pharmacology
- Receptors & Transporters
- Enzyme-Linked Receptors
- Receptor tyrosine kinases
- PDGFR
- Metabolism
- Pathways and Processes
- Metabolic signaling pathways
- Lipid and lipoprotein metabolism
- Cholesterol Metabolism
- Metabolism
- Pathways and Processes
- Metabolic signaling pathways
- Lipid and lipoprotein metabolism
- Lipoprotein metabolism
