Radicicol, Heat shock protein (HSP) 90 inhibitor (ab141848)
Key features and details
- Heat shock protein 90 inhibitor. Antifungal antibiotic.
- CAS Number: 12772-57-5
- Purity: > 99%
- Soluble in ethanol to 25 mM
- Form / State: Solid
- Source: Humicola fuscoatra
Overview
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Product name
Radicicol, Heat shock protein (HSP) 90 inhibitor -
Description
Heat shock protein 90 inhibitor. Antifungal antibiotic. -
Biological description
Heat shock protein 90 inhibitor and antifungal antibiotic. Binds to the N-terminal ATP/ADP-binding domain suppressing cell transformation induced by src, ras and mos. Induces cell cycle arrest at G1-S phase. Shows antiangiogenic effects in vivo. -
Purity
> 99% -
CAS Number
12772-57-5 -
Chemical structure
Properties
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Chemical name
(1aR,2Z,4E,14R,15aR)-8-Chloro-9,11-dihydroxy-14-methyl-1a,14,15,15a-tetrahydro-6H-oxireno[e][2]benzoxacyclotetradecine-6,12(7H)-dione -
Molecular weight
364.80 -
Molecular formula
C18H17ClO6 -
PubChem identifier
6323491 -
Storage instructions
Store at -20°C. Store under desiccating conditions. The product can be stored for up to 12 months. -
Solubility overview
Soluble in ethanol to 25 mM -
Handling
Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.
Toxic, refer to SDS for further information.
Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.
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SMILES
CC1CC2C(O2)C=CC=CC(=O)CC3=C(C(=CC(=C3Cl)O)O)C(=O)O1 -
Source
Humicola fuscoatra
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Research areas
