Quetiapine hemifumarate, D2 and 5-HT2 antagonis (ab120737)
Key features and details
- D2 and 5-HT2 antagonist. Antipsychotic.
- CAS Number: 111974-72-2
- Purity: > 99%
- Soluble in DMSO to 25 mM (with sonication)
- Form / State: Solid
- Source: Synthetic
Overview
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Product name
Quetiapine hemifumarate, D2 and 5-HT2 antagonis -
Description
D2 and 5-HT2 antagonist. Antipsychotic. -
Biological description
D2 and 5-HT2 antagonist. IC50 values (nM) are 329 (D2), 1243 (D1), 148 (5-HT2), 720 (5-HT1A), 90 (α1), 270 (α2), muscarinic (>10,000) and benzodiazepine (>10,000). Antipsychotic. Centrally active following oral administration.
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Purity
> 99% -
CAS Number
111974-72-2 -
Chemical structure
Properties
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Chemical name
2-[2-(4-Dibenzo[b,f][1,4]thiazepin-11-yl-1-piperazinyl)ethoxy]ethanol hemifumarate -
Molecular weight
441.54 -
Molecular formula
C21H25N3O2S.0.5C4H4O4 -
Storage instructions
Store at +4°C. Store under desiccating conditions. The product can be stored for up to 12 months. -
Solubility overview
Soluble in DMSO to 25 mM (with sonication) -
Handling
Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.
Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.
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Source
Synthetic
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Research areas
