Dibenzazepine (ab270805)
Key features and details
- Potent gamma secretase inhbitor
- CAS Number: 209984-56-5
- Purity: >= 98%
Soluble in DMSO to 100 mM and in ethanol to 25 mM
- Form / State: Solid
- Source: Synthetic
Overview
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Product name
Dibenzazepine -
Description
Potent gamma secretase inhbitor -
Biological description
Potent gamma secretase inhbitor (IC50 = 2.6 nM for APPL cleavage; IC50 = 2.9 nM for Notch cleavage). Inhibits Notch signaling. Neuroprotective, anti-diabetic, anti-fibrotic and cardioprotective in animal models. Blocks formation of abdominal aortic aneurysms. Inhibits AT-II induced angiogenesis and Th2 immune responses in animal aging models.
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Purity
>= 98% -
CAS Number
209984-56-5 -
Chemical structure
Properties
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Chemical name
N-[(1S)-2-[[(7S)-6,7-Dihydro-5-methyl-6-oxo-5H-dibenz[b,d]azepin-7-yl]amino]-1-methyl-2-oxoethyl]-3,5-difluoro-benzeneacetamide
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Molecular weight
463.48 -
Molecular formula
C26H23F2N3O3 -
PubChem identifier
11454028 -
Storage instructions
Shipped at room temperature. Store at -20°C. -
Solubility overview
Soluble in DMSO to 100 mM and in ethanol to 25 mM
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Handling
Refer to SDS for further information
Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.
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SMILES
C[C@@H](C(=O)N[C@H]1C2=CC=CC=C2C3=CC=CC=C3N(C1=O)C)NC(=O)CC4=CC(=CC(=C4)F)F -
Source
Synthetic
Images
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Chemical Structure - Dibenzazepine (ab270805)
Chemical structure of Dibenzazepine, 209984-56-5