Pyroxamide, HDAC1 inhibitor (ab144633)
Key features and details
- Potent cell permeable HDAC1 inhibitor
- CAS Number: 382180-17-8
- Purity: > 95%
- Soluble in DMSO to 100 mM
- Form / State: Solid
- Source: Synthetic
Overview
-
Product name
Pyroxamide, HDAC1 inhibitor -
Description
Potent cell permeable HDAC1 inhibitor -
Biological description
Potent cell permeable HDAC1 inhibitor (IC50 = 100 nM). Induces p21/WAF1 and differentiation. Inhibits cell growth by inducing cell-cycle arrest and initiates apoptosis. Shows antitumor effects in vivo. -
Purity
> 95% -
CAS Number
382180-17-8 -
Chemical structure
Properties
-
Chemical name
N'-Hydroxy-N-pyridin-3-yloctanediamide -
Molecular weight
265.31 -
Molecular formula
C13H19N3O3 -
PubChem identifier
4996 -
Storage instructions
Store at -20°C. Store under desiccating conditions. The product can be stored for up to 12 months. -
Solubility overview
Soluble in DMSO to 100 mM -
Handling
Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.
Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.
-
SMILES
C1=CC(=CN=C1)NC(=O)CCCCCCC(=O)NO -
Source
Synthetic
-
Research areas