PYR-41, Ubiquitin-activating enzyme (E1) inhibitor (ab141469)
Key features and details
- Ubiquitin-activating enzyme (E1) inhibitor
- CAS Number: 418805-02-4
- Purity: > 98%
- Soluble in DMSO to 50 mM
- Form / State: Solid
- Source: Synthetic
Overview
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Product name
PYR-41, Ubiquitin-activating enzyme (E1) inhibitor -
Description
Ubiquitin-activating enzyme (E1) inhibitor -
Biological description
Ubiquitin-activating enzyme (E1) inhibitor (IC50 = 5 µM). Inhibits ubiquitination and proteasomal degradation. Additionally increases sumoylation of proteins and induces p53-mediated apoptosis. -
Purity
> 98% -
CAS Number
418805-02-4 -
Chemical structure
Properties
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Chemical name
Ethyl 4-[(4Z)-4-[(5-nitrofuran-2-yl)methylidene]-3,5-dioxopyrazolidin-1-yl]benzoate -
Molecular weight
371.30 -
Molecular formula
C17H13N3O7 -
PubChem identifier
5335621 -
Storage instructions
Store at -20°C. Store under desiccating conditions. The product can be stored for up to 12 months. -
Solubility overview
Soluble in DMSO to 50 mM -
Handling
Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.
Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.
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SMILES
CCOC(=O)C1=CC=C(C=C1)N2C(=O)C(=CC3=CC=C(O3)[N+](=O)[O-])C(=O)N2 -
Source
Synthetic
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Research areas
