PT-2385, hypoxia inducible factor (ab235501)
Key features and details
- Potent and selective inhibitor of hypoxia inducible factor
- CAS Number: 1672665-49-4
- Purity: > 98%
DMSO
- Form / State: Solid
- Source: Synthetic
Overview
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Product name
PT-2385, hypoxia inducible factor -
Description
Potent and selective inhibitor of hypoxia inducible factor -
Biological description
Potent and selective inhibitor of hypoxia inducible factor (HIF-2α) with potential antineoplastic activity. PT-2385 selectively disrupts the heterodimerization of HIF-2α with HIF-1β. Very effective in blocking cancer cell growth, proliferation, and tumor angiogenesis in clear cell renal cell carcinoma (ccRCC).
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Purity
> 98% -
CAS Number
1672665-49-4 -
Chemical structure
Properties
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Chemical name
(S)-3-((2,2-difluoro-1-hydroxy-7-(methylsulfonyl)-2,3-dihydro-1H-inden-4-yl)oxy)-5-fluorobenzonitrile
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Molecular weight
383.34 -
Molecular formula
C17H12F3NO4S -
PubChem identifier
91754484 -
Storage instructions
Shipped at Room Temperature. Store at -20°C. It is important to note that this is air sensitive and impurities can occur as a result of air oxidation. Store In the Dark. Store under desiccating conditions. -
Solubility overview
DMSO
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Handling
Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.
Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.
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SMILES
CS(=O)(=O)C1=C2C(C(CC2=C(C=C1)OC3=CC(=CC(=C3)C#N)F)(F)F)O -
Source
Synthetic
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Research areas
