PR 619, DUB inhibitor (ab144641)
Key features and details
- Cell-permeable, non-selective and reversible DUB inhibitor
- CAS Number: 2645-32-1
- Purity: > 99%
- Soluble in DMSO to 100 mM
- Form / State: Solid
- Source: Synthetic
Overview
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Product name
PR 619, DUB inhibitor -
Description
Cell-permeable, non-selective and reversible DUB inhibitor -
Biological description
Cell-permeable, non-selective and reversible DUB inhibitor (IC50 values are 5 to 20 μM). Induces polyubiquitinated protein accumulation in cells without directly affecting proteasome activity. Activates autophagy.
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Purity
> 99% -
CAS Number
2645-32-1 -
Chemical structure
Properties
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Chemical name
Thiocyanic acid 2,6-diamino-3,5-pyridinediyl ester -
Molecular weight
223.27 -
Molecular formula
C7H5N5S2 -
PubChem identifier
2817763 -
Storage instructions
Store at -20°C. Store under desiccating conditions. The product can be stored for up to 12 months. -
Solubility overview
Soluble in DMSO to 100 mM -
Handling
Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.
Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.
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SMILES
C1=C(C(=NC(=C1SC#N)N)N)SC#N -
Source
Synthetic
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Research areas
