PQ 401, Cell-permeable IGF1R inhibitor (ab141077)
Key features and details
- Cell-permeable IGF1R inhibitor
- CAS Number: 196868-63-0
- Purity: > 99%
- Soluble in DMSO to 100 mM and in ethanol to 10 mM
- Form / State: Solid
- Source: Synthetic
Overview
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Product name
PQ 401, Cell-permeable IGF1R inhibitor -
Description
Cell-permeable IGF1R inhibitor -
Biological description
Cell-permeable IGF1R inhibitor (IC50 = 12 μM for IGF-stimulated autophosphorylation). Shows antiproliferative effects against MCF-7 breast cancer cells. Induces renal hypertrophy in vivo.
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Purity
> 99% -
CAS Number
196868-63-0 -
Chemical structure
Properties
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Chemical name
N-(5-Chloro-2-methoxyphenyl)-N'-(2-methyl-4-quinolinyl)urea -
Molecular weight
341.80 -
Molecular formula
C18H16ClN3O2 -
PubChem identifier
9549305 -
Storage instructions
Store at +4°C. The product can be stored for up to 12 months. -
Solubility overview
Soluble in DMSO to 100 mM and in ethanol to 10 mM -
Handling
Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.
Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.
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SMILES
Clc3cc(NC(=O)Nc1cc(C)nc2ccccc12)c(OC)cc3 -
Source
Synthetic
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Research areas
