Piceatannol, Syk tyrosine kinase inhibitor (ab120722)
Key features and details
- Syk tyrosine kinase inhibitor
- CAS Number: 10083-24-6
- Purity: > 99%
- Soluble in DMSO to 100 mM and in ethanol to 100 mM
- Form / State: Solid
- Source: Synthetic
Overview
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Product name
Piceatannol, Syk tyrosine kinase inhibitor -
Description
Syk tyrosine kinase inhibitor -
Biological description
Syk tyrosine kinase inhibitor (Ki = 15 μM at Syk). Shows multiple biological activities such as anti-inflammatory, antiproliferative and immunomodulatory effects.
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Purity
> 99% -
CAS Number
10083-24-6 -
Chemical structure
Properties
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Chemical name
4-[(1E)-2-(3,5-Dihydroxyphenyl)ethenyl]-1,2-benzenediol -
Molecular weight
244.25 -
Molecular formula
C14H12O4 -
Storage instructions
Store at +4°C. Store under desiccating conditions. The product can be stored for up to 12 months. -
Solubility overview
Soluble in DMSO to 100 mM and in ethanol to 100 mM -
Handling
Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.
Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.
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Source
Synthetic
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Research areas
Images
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Functional Studies - Piceatannol, Syk tyrosine kinase inhibitor (ab120722)ab119954 staining CBL in A431 cells treated with piceatannol (ab120722), by ICC/IF. Decrease in CBL expression correlates with increased concentration of piceatannol, as described in literature.
The cells were incubated at 37°C for 1h in media containing different concentrations of ab120722 (piceatannol) in DMSO, fixed with 4% formaldehyde for 10 minutes at room temperature and blocked with PBS containing 10% goat serum, 0.3 M glycine, 1% BSA and 0.1% tween for 2h at room temperature. Staining of the treated cells with ab119954 (5 µg/ml) was performed overnight at 4°C in PBS containing 1% BSA and 0.1% tween. A DyLight 488 goat anti-mouse polyclonal antibody (ab96879) at 1/250 dilution was used as the secondary antibody. Nuclei were counterstained with DAPI and are shown in blue.
