PFI-2, SETD7 histone lysine methyltransferase inhibitor (ab223601)
Key features and details
- Potent and selective SETD7 histone lysine methyltransferase inhibitor
- CAS Number: 1627676-59-8
- Purity: > 98%
- Soluble in DMSO to 50 mM
- Form / State: Solid
- Source: Synthetic
Overview
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Product name
PFI-2, SETD7 histone lysine methyltransferase inhibitor -
Description
Potent and selective SETD7 histone lysine methyltransferase inhibitor -
Biological description
A potent and selective SETD7 histone lysine methyltransferase inhibitor. Ki = 0.33 nM and IC50 = 2 nM against SETD7. It displays > 1000-fold selectivity against DNMT1 and many other methyltransferases. No activity against 134 ion channel, GPCR, and enzyme targets (
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Purity
> 98% -
General notes
Protect from air.
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CAS Number
1627676-59-8 -
Chemical structure
Properties
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Chemical name
(R)-8-Fluoro-N-(1-oxo-1-(pyrrolidin-1-yl)-3-(3-(trifluoromethyl)phenyl)propan-2-yl)-1,2,3,4-tetrahydroisoquinoline-6-sulfonamide -
Molecular weight
499.52 -
Molecular formula
C23H25F4N3O3S -
PubChem identifier
71300326 -
Storage instructions
Shipped at 4°C. Store at -20°C. Store In the Dark. -
Solubility overview
Soluble in DMSO to 50 mM -
Handling
Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.
Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.
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SMILES
C1CCN(C1)C(=O)[C@@H](CC2=CC(=CC=C2)C(F)(F)F)NS(=O)(=O)C3=CC(=C4CNCCC4=C3)F -
Source
Synthetic
