Pexidartinib, CSF1R inhibitor (ab254454)
Key features and details
- Potent and selective MCSF Receptor inhibitor
- CAS Number: 1029044-16-3
- Purity: > 98%
Soluble in DMSO to 10 mM
- Form / State: Solid
- Source: Synthetic
Overview
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Product name
Pexidartinib, CSF1R inhibitor -
Description
Potent and selective MCSF Receptor inhibitor -
Alternative names
- PLX3397
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Biological description
Potent MCSF Receptor (CSF1R) inhibitor (IC50 = 13 nM). Also inhibits Kit (IC50 = 16 nM) and Flt3 (IC50 = 160 nM). Highly selective (IC50 >1 μM) against a panel of over 200 kinases. Inhibits MCSF Receptor-dependent proliferation (0.1 - 0.44 μM) in cell models. Inhibits glioblastoma invasion in mouse xenograft models.
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Purity
> 98% -
General notes
Solutions in DMSO may be stored at -20°C for up to 2 months.
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CAS Number
1029044-16-3 -
Chemical structure
Properties
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Chemical name
5-[(5-Chloro-1H-pyrrolo[2,3-b]pyridin-3-yl)methyl]-N-[[6-(trifluoromethyl)pyridin-3-yl]methyl]pyridin-2-amine
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Molecular weight
417.82 -
Molecular formula
C20H15ClF3N5 -
PubChem identifier
25151352 -
Storage instructions
Shipped at Room Temperature. Store at -20°C. Store under desiccating conditions. -
Solubility overview
Soluble in DMSO to 10 mM
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Handling
Refer to SDS for more information.
Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.
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SMILES
C1=CC(=NC=C1CC2=CNC3=NC=C(C=C23)Cl)NCC4=CN=C(C=C4)C(F)(F)F -
Source
Synthetic
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Research areas
