Pelitinib (EKB-569), Irreversible EGFR inhibitor (ab141171)
Key features and details
- Irreversible EGFR inhibitor
- CAS Number: 257933-82-7
- Purity: > 98%
- Soluble in ethanol to 25 mM
- Form / State: Solid
- Source: Synthetic
Overview
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Product name
Pelitinib (EKB-569), Irreversible EGFR inhibitor -
Description
Irreversible EGFR inhibitor -
Alternative names
- EKB-569
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Biological description
Irreversible EGFR inhibitor (IC50 = 38.5 nM). Greater inhibitory activity against EGFR then erbB-2, Src, Cdk4, c-Met, Raf, MEK/ERK (IC50 values are 1255, 282, >20,000, 4100, 3353 and 800 nM respectively). Active in vivo.
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Purity
> 98% -
CAS Number
257933-82-7 -
Chemical structure
Properties
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Chemical name
(2E)-N-[4-[(3-Chloro-4-fluorophenyl)amino]-3-cyano-7-ethoxy-6-quinolinyl]-4-(dimethylamino)-2-butenamide -
Molecular weight
467.93 -
Molecular formula
C24H23ClFN5O2 -
PubChem identifier
6445562 -
Storage instructions
Store at -20°C. Store under desiccating conditions. The product can be stored for up to 12 months. -
Solubility overview
Soluble in ethanol to 25 mM -
Handling
Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.
Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.
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SMILES
CN(C)C\C=C\C(=O)Nc2cc3c(Nc1ccc(F)c(Cl)c1)c(cnc3cc2OCC)C#N -
Source
Synthetic
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Research areas