Oligomycin B, macrolide antibiotic (ab143424)
Key features and details
- Macrolide antibiotic. Mitochondrial ATPase inhibitor.
- CAS Number: 11050-94-5
- Purity: > 97%
- Soluble in DMSO and in ethanol
- Form / State: Solid
- Source: Streptomyces diastatochromogenes
Overview
-
Product name
Oligomycin B, macrolide antibiotic -
Description
Macrolide antibiotic. Mitochondrial ATPase inhibitor. -
Biological description
Macrolide antibiotic. Mitochondrial ATPase inhibitor. -
Purity
> 97% -
CAS Number
11050-94-5 -
Chemical structure
Properties
-
Molecular weight
805.05 -
Molecular formula
C45H72O12 -
PubChem identifier
71312640 -
Storage instructions
Store at +4°C. The product can be stored for up to 12 months. -
Solubility overview
Soluble in DMSO and in ethanol -
Handling
Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.
Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.
-
SMILES
CCC1CCC2C(C(C(C3(O2)C(=O)CC(C(O3)CC(C)O)C)C)OC(=O)C=CC(C(C(C(=O)C(C(C(C(=O)C(C(C(CC=CC=C1)C)O)(C)O)C)O)C)C)O)C)C -
Source
Streptomyces diastatochromogenes
-
Research areas
Images
-
Functional Studies - Oligomycin B, macrolide antibiotic (ab143424) Yang et al PLoS One. 2017; 12(5): e0177951. Reproduced under the Creative Commons license http://creativecommons.org/licenses/by/4.0/
Effects of metabolic inhibitors on cellular ATP.
Effect of metabolic inhibitors on cellular ATP was measured after 10 min in the presence of 10 mM glucose (A) or 0 mM glucose (B and C) (n = 4). Rote: 1 μM rotenone. Anti: 1 μM antimycin. Oligo: 6 μM oligomycin. CCCP: 1 μM CCCP. 2-DG: 5 mM 2-DG. Significant difference was assessed using ANOVA. Note that rotenone application in the presence of 10 mM glucose (panel A second from left) did not cause significant change, but all other treatments with metabolic inhibitors significantly changed luminescence reading against control values.
(From Figure 5 of Yang et al).
