Entacapone, COMT inhibitor (ab142298)
Key features and details
- Potent, selective, and reversible COMT inhibitor
- CAS Number: 116314-67-1
- Purity: > 98%
- Soluble in DMSO to 100 mM
- Form / State: Solid
- Source: Synthetic
Overview
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Product name
Entacapone, COMT inhibitor -
Description
Potent, selective, and reversible COMT inhibitor -
Biological description
Potent, selective, and reversible COMT inhibitor (IC50 = 151 nM). Inhibits α-syn and β-amyloid (Aβ) oligomerization and fibrillogenesis (IC50 = 100 μM). Potentiates L-dopa and attenuates associated motor fluctuations in vivo. Orally active. -
Purity
> 98% -
CAS Number
116314-67-1 -
Chemical structure
Properties
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Chemical name
2-Cyano-3-(3,4-dihydroxy-5-nitrophenyl)-N,N-diethylprop-2-enamide -
Molecular weight
305.29 -
Molecular formula
C14H15N3O5 -
PubChem identifier
4659568 -
Storage instructions
Store at Room Temperature. The product can be stored for up to 12 months. -
Solubility overview
Soluble in DMSO to 100 mM -
Handling
Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.
Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.
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SMILES
CCN(CC)C(=O)C(=CC1=CC(=C(C(=C1)O)O)[N+](=O)[O-])C#N -
Source
Synthetic
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Research areas