(-)-Nutlin-3, p53-MDM2 binding inhibitor (ab144428)
Key features and details
- Potent p53-MDM2 binding inhibitor
- CAS Number: 675576-98-4
- Purity: > 98%
- Soluble in DMSO
- Form / State: Solid
- Source: Synthetic
Overview
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Product name
(-)-Nutlin-3, p53-MDM2 binding inhibitor -
Description
Potent p53-MDM2 binding inhibitor -
Alternative names
- Nutlin 3a
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Biological description
Potent p53-MDM2 binding inhibitor (IC50 = 90 nM). Enantiomer of (+)-Nutlin-3 (ab144426). Shows antiproliferative effects (IC50 values are 2.2 and 1.3 µM for human skin and murine fibroblasts respectively). Shows antitumor effects in vivo. Orally active.
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Purity
> 98% -
CAS Number
675576-98-4 -
Chemical structure
Properties
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Chemical name
4-[(4S,5R)-4,5-Bis(4-chlorophenyl)-2-(4-methoxy-2-propan-2-yloxyphenyl)-4,5-dihydroimidazole-1-carbonyl]piperazin-2-one -
Molecular weight
581.50 -
Molecular formula
C30H30Cl2N4O4 -
PubChem identifier
11433190 -
Storage instructions
Store at -20°C. Store under desiccating conditions. The product can be stored for up to 12 months. -
Solubility overview
Soluble in DMSO -
Handling
Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.
Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.
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SMILES
CC(C)OC1=C(C=CC(=C1)OC)C2=N[C@H]([C@H](N2C(=O)N3CCNC(=O)C3)C4=CC=C(C=C4)Cl)C5=CC=C(C=C5)Cl -
Source
Synthetic
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Research areas
