NSC 66811, MDM2 inhibitor (ab142190)
Key features and details
- Potent, cell-permeable MDM2 inhibitor
- CAS Number: 6964-62-1
- Purity: > 97%
- Soluble in DMSO to 100 mM
- Form / State: Solid
- Source: Synthetic
Overview
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Product name
NSC 66811, MDM2 inhibitor -
Description
Potent, cell-permeable MDM2 inhibitor -
Biological description
Potent, cell-permeable MDM2 inhibitor (Ki = 120 nM). Disrupts MDM2-p53 interaction and activates p53 function. Induces p21, p53 and MDM2 accumulation in human colon cancer cells. -
Purity
> 97% -
CAS Number
6964-62-1 -
Chemical structure
Properties
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Chemical name
7-[Anilino(phenyl)methyl]-2-methylquinolin-8-ol -
Molecular weight
340.42 -
Molecular formula
C23H20N2O -
PubChem identifier
248986 -
Storage instructions
Store at -20°C. Store under desiccating conditions. The product can be stored for up to 12 months. -
Solubility overview
Soluble in DMSO to 100 mM -
Handling
Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.
Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.
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SMILES
CC1=NC2=C(C=C1)C=CC(=C2O)C(C3=CC=CC=C3)NC4=CC=CC=C4 -
Source
Synthetic
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Research areas
