Genipin, Cell-permeable uncoupling protein 2 inhibitor (ab141049)
Key features and details
- Cell-permeable uncoupling protein 2 inhibitor
- CAS Number: 6902-77-8
- Purity: > 99%
- Soluble in DMSO to 100 mM and in ethanol to 50 mM
- Form / State: Solid
- Source: Synthetic
Overview
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Product name
Genipin, Cell-permeable uncoupling protein 2 inhibitor -
Description
Cell-permeable uncoupling protein 2 inhibitor -
Biological description
Cell-permeable uncoupling protein 2 (UCP2) inhibitor. Anti-inflammatory, anti-angiogenic and pro-apototic effects. Acts as a protein cross-linker.
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Purity
> 99% -
CAS Number
6902-77-8 -
Chemical structure
Properties
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Chemical name
(1R,4aS,7aS)-1,4a,5,7a-Tetrahydro-1-hydroxy-7-(hydroxymethyl)cyclopenta[c]pyran-4-carboxylic acid methyl ester -
Molecular weight
226.23 -
Molecular formula
C11H14O5 -
Storage instructions
Store at +4°C. The product can be stored for up to 12 months. -
Solubility overview
Soluble in DMSO to 100 mM and in ethanol to 50 mM -
Handling
Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.
Toxic, refer to SDS for further information.
Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.
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SMILES
O=C(OC)C1=CO[C@@H](O)[C@@H]2C(=CC[C@H]12)CO -
Source
Synthetic
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Research areas
Images
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Functional Studies - Genipin, Cell-permeable uncoupling protein 2 inhibitor (ab141049)ab28 staining p53 in HeLa cells treated with genipin (ab141049), by ICC/IF. Increase of p53 expression correlates with increased concentration of genipin, as described in literature.
The cells were incubated at 37°C for 6h in media containing different concentrations of ab141049 (genipin) in DMSO, fixed with 4% formaldehyde for 10 minutes at room temperature and blocked with PBS containing 10% goat serum, 0.3 M glycine, 1% BSA and 0.1% tween for 2h at room temperature. Staining of the treated cells with ab28 (5 µg/ml) was performed overnight at 4°C in PBS containing 1% BSA and 0.1% tween. A DyLight 488 anti-mouse polyclonal antibody (ab96879) at 1/250 dilution was used as the secondary antibody. Nuclei were counterstained with DAPI and are shown in blue.
