Noscapine, antimitotic agent (ab215525)
Key features and details
- Antitussive, antimitotic agent; non-addictive.
- CAS Number: 128-62-1
- Form / State: Solid
Overview
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Product name
Noscapine, antimitotic agent -
Description
Antitussive, antimitotic agent; non-addictive. -
Alternative names
- (-)-Narcotine
- 3S)-6,7-Dimethoxy-3-[(5R)-5,6,7,8-tetrahydro-4-methoxy-6-methyl-1,3-dioxolo[4,5-g]isoquinolin-5-yl]-1(3H)-isobenzofuranone
- Capval
see all -
Biological description
A phthalide isoquinoline non-narcotic alkaloid derived from the opium poppy Papaver somniferum, with antitussive, and potential antineoplastic activities. Exerts its antitussive effects through the activation of sigma opioid receptors. Exerts its antimitotic effect by binding to tubulin, resulting in a disruption of microtubule assembly dynamics and subsequently, the inhibition of mitosis and tumor cell death.
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CAS Number
128-62-1 -
Chemical structure
Properties
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Chemical name
3S)-6,7-dimethoxy-3-[(5R)-4-methoxy-6-methyl-7,8-dihydro-5H-[1,3]dioxolo[4,5-g]isoquinolin-5-yl]-3H-2-benzofuran-1-one
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Molecular weight
413.42 -
Molecular formula
C22H23NO7 -
PubChem identifier
275196 -
Storage instructions
Shipped at 4°C. Store at -20°C. Store under desiccating conditions. -
Handling
Under Inert Atmosphere.
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SMILES
COc1c5OCOc5cc2CCN(C)[C@H](c12)[C@H]4OC(=O)c3c(OC)c(ccc34)OC
