Nimbolide, CyclinA and ERK1/2 inhibitor (ab142138)
Key features and details
- CyclinA and ERK1/2 inhibitor. Terpenoid lactone.
- CAS Number: 25990-37-8
- Purity: > 97%
- Soluble in DMSO to 100 mM
- Form / State: Solid
- Source: Azadirachta indica
Overview
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Product name
Nimbolide, CyclinA and ERK1/2 inhibitor -
Description
CyclinA and ERK1/2 inhibitor. Terpenoid lactone. -
Biological description
CyclinA and ERK1/2 inhibitor. Terpenoid lactone derived from Azadirachta indica. Proapoptotic and anticancer activity in vivo.
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Purity
> 97% -
CAS Number
25990-37-8 -
Chemical structure
Properties
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Chemical name
(2aR,5aR,6S,6aR,8R,9aR,10aS,10bR,10cR)- 8-(3-Furanyl)-2a,5a,6,6a,8,9,9a,10a,10b,10c-decahydro-2a,5a,6a,7-tetramethyl-2,5-dioxo-2H,5H-cyclopenta[d']naphtho[1,8-bc:2,3-b']difuran-6-acetic acid methyl ester -
Molecular weight
466.53 -
Molecular formula
C27H30O7 -
PubChem identifier
100017 -
Storage instructions
Store at -20°C. Store under desiccating conditions. The product can be stored for up to 12 months. -
Solubility overview
Soluble in DMSO to 100 mM -
Handling
Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.
Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.
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SMILES
CC1=C2C(CC1C3=COC=C3)OC4C2(C(C5(C6C4OC(=O)C6(C=CC5=O)C)C)CC(=O)OC)C -
Source
Azadirachta indica
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Research areas