Netropsin dihydrochloride, DNA minor groove binding ligand (ab146342)
Key features and details
- DNA minor groove binding ligand.
- CAS Number: 1438-30-8
- Purity: > 98%
- Soluble in water (1 mg/mL)
- Form / State: Solid
- Source: Streptomyces netropsis
Overview
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Product name
Netropsin dihydrochloride, DNA minor groove binding ligand -
Description
DNA minor groove binding ligand. -
Alternative names
- 4-([((Aminoiminomethyl)amino)acetyl)amino)-N-(5-(((3-amino-3-iminopropyl)amino)carbonyl]-1-methyl-1H-pyrrol-3-yl)-1-methyl-1H-pyrrole-3-carboxamide
- Congocidin
- Sinanomycin
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Biological description
DNA minor groove binding ligand with potential antibiotic and antiviral properties. Binds to AT-rich regions in dsDNA, and has the ability to block DNA helicase, Topoisomerase and endonuclease, and also to interfere with transcription factor binding in these regions. Binds to dsDNA in a non-intercalative manner.
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Purity
> 98% -
CAS Number
1438-30-8 -
Chemical structure
Properties
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Chemical name
N-[4-[(3-Amino-3-iminopropyl)carbamoyl]-1-methylpyrrol-3-yl]-4-[[2-(diaminomethylideneamino)acetyl]amino]-1-methylpyrrole-2-carboxamide dihydrochloride -
Molecular weight
503.39 -
Molecular formula
C18H26N10O3.2HCl -
PubChem identifier
16219788 -
Storage instructions
Store at -20°C (desiccating conditions). -
Solubility overview
Soluble in water (1 mg/mL) -
Handling
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Source
Streptomyces netropsis
