Belnacasan (VX-765) (ab273602)
Key features and details
- Potent and selective caspase-1 inhibitor
- CAS Number: 273404-37-8
- Purity: > 98%
Soluble in DMSO to 50 mM and in ethanol to 50 mM
- Form / State: Solid
- Source: Synthetic
Overview
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Product name
Belnacasan (VX-765) -
Description
Potent and selective caspase-1 inhibitor -
Alternative names
- VX-765
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Biological description
Potent and selective inhibitor against caspase-1 with Ki of 0.8 nM. Orally absorbed. Also inhibits IL-1β release from both PBMCs and whole blood with IC50 of 0.67 μM and 1.9 μM, in vitro. Inhibits LPS-induced IL-1β production in collagen-induced arthritis mouse model, in vivo.
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Purity
> 98% -
CAS Number
273404-37-8 -
Chemical structure
Properties
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Chemical name
N-(4-Amino-3-chlorobenzoyl)-3-methyl-L-valyl-N-[(2R,3S)-2-ethoxytetrahydro5-oxo-3-furanyl]-L-prolinamide
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Molecular weight
508.99 -
Molecular formula
C24H33ClN4O6 -
PubChem identifier
11398092 -
Storage instructions
Shipped at room temperature. Store at -20°C. -
Solubility overview
Soluble in DMSO to 50 mM and in ethanol to 50 mM
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Handling
Refer to SDS for further information
Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.
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SMILES
CCO[C@H]1[C@H](CC(=O)O1)NC(=O)[C@@H]2CCCN2C(=O)[C@H](C(C)(C)C)NC(=O)C3=CC(=C(C=C3)N)Cl -
Source
Synthetic
Images
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Belnacasan (VX-765) (ab273602)