Necrosulfonamide, necroptosis inhibitor (ab143839)
Key features and details
- Potent, selective necroptosis inhibitor. MLKL blocker.
- CAS Number: 432531-71-0
- Purity: > 98%
- Soluble in DMSO to 25 mM
- Form / State: Solid
- Source: Synthetic
Overview
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Product name
Necrosulfonamide, necroptosis inhibitor -
Description
Potent, selective necroptosis inhibitor. MLKL blocker. -
Biological description
Potent, selective necroptosis inhibitor (IC50 = 0.2 μM). MLKL blocker. Selectively blocks necrosis downstream of RIP3 activation. Shows selective antinecrotic effects.
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Purity
> 98% -
CAS Number
432531-71-0 -
Chemical structure
Properties
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Chemical name
(E)-N-[4-[[(3-Methoxy-2-pyrazinyl)amino]sulfonyl]phenyl]-3-(5-nitro-2-thienyl)-2-propenamide -
Molecular weight
461.47 -
Molecular formula
C18H15N5O6S2 -
PubChem identifier
1566236 -
Storage instructions
Store at -20°C. It is important to note that this product is reported to be light sensitive. Store In the Dark. Store under desiccating conditions. -
Solubility overview
Soluble in DMSO to 25 mM -
Handling
Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.
Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.
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SMILES
COC1=NC=CN=C1NS(=O)(=O)C2=CC=C(C=C2)NC(=O)C=CC3=CC=C(S3)[N+](=O)[O-] -
Source
Synthetic
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Research areas
