Antibodies, Proteins, Kits and Reagents for Life Science

Key features and details

Expression system: Native
Suitable for: IA, ELISA

Product name

Native Human SHBG protein
See all SHBG proteins and peptides
Expression system

Native
Protein length

Full length protein
Animal free

No
Nature

Native
- Species
  
  Human
- Predicted molecular weight
  
  45 kDa

Alternative names
- ABP
- Androgen binding protein
- SBP
- Sex hormone-binding globulin
- Sex steroid binding protein
- Sex steroid-binding protein
- SHBG
- SHBG_HUMAN
- TeBG
- Testis specific androgen binding protein
- Testis-specific androgen-binding protein
- Testosterone binding beta globulin
- Testosterone estradiol binding globulin
- Testosterone estrogen binding globulin
- Testosterone-estradiol-binding globulin
- Testosterone-estrogen-binding globulin
see all
Function

Functions as an androgen transport protein, but may also be involved in receptor mediated processes. Each dimer binds one molecule of steroid. Specific for 5-alpha-dihydrotestosterone, testosterone, and 17-beta-estradiol. Regulates the plasma metabolic clearance rate of steroid hormones by controlling their plasma concentration.
Tissue specificity

Isoform 1 and isoform 2 are present in liver and testis.
Sequence similarities

Contains 2 laminin G-like domains.
Cellular localization

Secreted. In testis, it is synthesized by the Sertoli cells, secreted into the lumen of the seminiferous tubule and transported to the epididymis.
Target information above from: UniProt accession P04278 The UniProt Consortium
The Universal Protein Resource (UniProt) in 2010
Nucleic Acids Res. 38:D142-D148 (2010) .

Information by UniProt

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