Narciclasine, Rho/LIM kinase/cofilin signaling pathway activator (ab218110)
Key features and details
- Rho/Rho kinase/LIM kinase/cofilin signaling pathway activator
- CAS Number: 29477-83-6
- Purity: > 98%
- Soluble in DMSO to 100 mM
- Form / State: Solid
- Source: Synthetic
Overview
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Product name
Narciclasine, Rho/LIM kinase/cofilin signaling pathway activator -
Description
Rho/Rho kinase/LIM kinase/cofilin signaling pathway activator -
Alternative names
- BRN 1087400
- Lycoricidin-A
- Lycoricidinol
- NSC 266535
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Biological description
Plant growth regulator originally isolated from Narcissus bulbs. Exhibits antiproliferative and pro-apoptotic effects in carcinoma cells and displays cytotoxic activity against a panel of 60 cancer cell lines (mean IC50 = 47 nM). Activity decreases rate of cell division and increases mitosis duration in vitro. Also modulates the Rho/ROCK/LIM kinase/cofilin pathway; stimulates RhoA activation and induces actin polymerization.
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Purity
> 98% -
CAS Number
29477-83-6 -
Chemical structure
Properties
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Chemical name
(2S,3R,4S,4aR)-3,4,4a,5-Tetrahydro-2,3,4,7-tetrahydroxy-(1,3)-dioxolo(4,5-j)phenanthridin-6(2H)-one -
Molecular weight
307.26 -
Molecular formula
C14H13NO7 -
PubChem identifier
72376 -
Storage instructions
Shipped at 4°C. Store at -20°C. Store under desiccating conditions. -
Solubility overview
Soluble in DMSO to 100 mM -
Handling
Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.
Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.
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SMILES
C1OC2=C(O1)C(=C3C(=C2)C4=C[C@@H]([C@H]([C@H]([C@@H]4NC3=O)O)O)O)O -
Source
Synthetic
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Research areas
