(+)-MK 801 maleate (Dizocilpine), Non-competitive NMDA antagonist (ab120027)
Key features and details
- Non-competitive NMDA antagonist
- CAS Number: 77086-22-7
- Purity: > 99%
- Soluble in water to 25 mM
- Form / State: Solid
- Source: Synthetic
Overview
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Product name
(+)-MK 801 maleate (Dizocilpine), Non-competitive NMDA antagonist -
Description
Non-competitive NMDA antagonist -
Alternative names
- Dizocilpine
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Biological description
Potent, selective non-competitive NMDA receptor antagonist. Open channel blocker of the NMDA receptor operated ion channel.
Also available in simple stock solutions (ab144485) - add 1 ml of water to get an exact, ready-to-use concentration. -
Purity
> 99% -
CAS Number
77086-22-7 -
Chemical structure
Properties
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Chemical name
(5S,10R)-(+)-5-Methyl-10,11-dihydro-5H-dibenzo[a,d]cyclohepten-5,10-imine maleate -
Molecular weight
337.37 -
Molecular formula
C16H15N.C4H4O4 -
PubChem identifier
6420042 -
Storage instructions
Store at +4°C. Store under desiccating conditions. The product can be stored for up to 12 months. -
Solubility overview
Soluble in water to 25 mM -
Handling
Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.
Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.
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SMILES
O=C(O)/C=CC(=O)O.C[C@@]42N[C@H](Cc1ccccc12)c3ccccc34 -
Source
Synthetic
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Research areas
Images
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Functional Studies - (+)-MK 801 maleate (Dizocilpine), Non-competitive NMDA antagonist (ab120027) Image from Fowler SW et al., Neurobiol Learn Mem. 2010;95(1):73-9. Fig 2(B).; doi: 10.1016/j.nlm.2010.11.009 with permission from Elsevier.CDPPB does not influence spontaneous locomotor activity but attenuates MK-801-induced hyperlocomotion. Animals were injected (s.c./i.p.) with PBS/Vehicle (0/0), 0.2 mg/kg MK-801/Vehicle (0.2/0), 0.2 mg/kg MK-801/3 mg/kg CDPPB (0.2/3) or 0.2 mg/kg MK-801/10 mg/kg CDPPB (0.2/10) 20 minutes before being placed in the activity chamber. Activity was recorded for 30 minutes. Data are expressed as mean ± SEM of distance traveled (n=6-7). **p
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