MI-3 (ab254236)
Key features and details
- Potent menin-MLL interaction inhibitor that blocks cell proliferation and induces apoptosis.
- CAS Number: 1271738-59-0
- Purity: > 98%
DMSO: 19 mg/ml
Insoluble in water
Alcohol: 19 mg/ml
- Form / State: Solid
- Source: Synthetic
Overview
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Product name
MI-3 -
Description
Potent menin-MLL interaction inhibitor that blocks cell proliferation and induces apoptosis. -
Alternative names
- Menin-MLL Inhibitor
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Biological description
Potent menin-MLL interaction inhibitor (IC50 of 648 nM). Inhibits the menin-MLL-AF9 interaction in HEK-293 cells. Blocks MLL fusion protein-mediated leukemic transformation by downregulating the expression of target genes required for MLL fusion protein oncogenic activity. Blocks cell proliferation and induces apoptosis in human MLL leukemia cell lines harboring different MLL translocations. Can induce differentiation in MLL fusion protein transformed cells.
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Purity
> 98% -
General notes
Wear gloves and mask when handling the product! Avoid contact by all modes of exposure. Protect from light and air.
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CAS Number
1271738-59-0 -
Chemical structure
Properties
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Chemical name
4-(4-(5,5-Dimethyl-4,5-dihydrothiazol-2-yl)piperazin-1-yl)-6-isopropylthieno[2,3-d]pyrimidine
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Molecular weight
375.55 -
Molecular formula
C18H25N5S2 -
PubChem identifier
51001299 -
Storage instructions
Shipped at 4°C. Store at -20°C long term. Store In the Dark. -
Solubility overview
DMSO: 19 mg/ml
Insoluble in water
Alcohol: 19 mg/ml
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Handling
Refer to SDS for further information.
Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.
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SMILES
CC(C)C1=NC(=C2C=CSC2=N1)N3CCN(CC3)C4=NCC(S4)(C)C -
Source
Synthetic
