S-Me-DM1, microtubule-targeting maytansinoid (ab216942)
Key features and details
- Microtubule-targeting maytansinoid
- CAS Number: 912569-84-7
Solubilizes at ~3mg/mL in DMSO, ~3mg/mL in Chloroform, and ~3mg/mL in MeOH
- Form / State: Solid
- Source: Synthetic
Overview
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Product name
S-Me-DM1, microtubule-targeting maytansinoid -
Description
Microtubule-targeting maytansinoid -
Alternative names
- Maytansinoid DM 1
- S-methyl DM1
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Biological description
Active metabolite of Maytansine (ab146096) that inhibits in vitro polymerization of tubulin. Accumulates in cells and induces mitotic arrest.
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CAS Number
912569-84-7 -
Chemical structure
Properties
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Chemical name
N2'-Deacetyl-N2'-(3-thiomethyl-1-oxopropyl)-maytansine
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Molecular weight
752.31 -
Molecular formula
C36H50ClN3O10S -
PubChem identifier
11343137 -
Storage instructions
Shipped at 4°C. Store at -20°C. Store under desiccating conditions. -
Solubility overview
Solubilizes at ~3mg/mL in DMSO, ~3mg/mL in Chloroform, and ~3mg/mL in MeOH
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Handling
Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.
Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.
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SMILES
C[C@@H]1[C@@H]2C[C@]([C@@H](/C=C/C=C(/CC3=CC(=C(C(=C3)OC)Cl)N(C(=O)C[C@@H]([C@]4([C@H]1O4)C)OC(=O)[C@H](C)N(C)C(=O)CCS)C)\C)OC)(NC(=O)O2)O -
Source
Synthetic
