Methotrexate hydrate, DHFR inhibitor (ab142445)
Key features and details
- Potent, competitive DHFR inhibitor and cell cycle arrest agent
- CAS Number: 6745-93-3
- Purity: > 98%
Not soluble in water or ethanol. Soluble in dilute HCl and in alkaline solution.
- Form / State: Solid
- Source: Synthetic
Overview
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Product name
Methotrexate hydrate, DHFR inhibitor -
Description
Potent, competitive DHFR inhibitor and cell cycle arrest agent -
Biological description
Potent, competitive dihydrofolate reductase inhibitor (IC50 = 2.6 nM). Induces late S/G2 cell cycle arrest and apoptosis. Antitumor, anti-inflammatory and antirheumatic agent. Active in vitro and in vivo. -
Purity
> 98% -
CAS Number
6745-93-3 -
Chemical structure
Properties
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Chemical name
N-[4-[[(2,4-Diamino-6-pteridinyl)methyl]methylamino]benzoyl]-L-glutamic acid hydrate
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Molecular weight
472.45 -
Molecular formula
C20H22N8O5.H2O -
PubChem identifier
165528 -
Storage instructions
Store at -20°C. Store under desiccating conditions. The product can be stored for up to 12 months. -
Solubility overview
Not soluble in water or ethanol. Soluble in dilute HCl and in alkaline solution.
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Handling
Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.
Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.
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SMILES
CN(CC1=CN=C2C(=N1)C(=NC(=N2)N)N)C3=CC=C(C=C3)C(=O)NC(CCC(=O)O)C(=O)O.O -
Source
Synthetic
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Research areas