Memantine hydrochloride, NMDA antagonist (ab120249)
Key features and details
- NMDA antagonist, ion channel site
- CAS Number: 41100-52-1
- Purity: > 98%
- Soluble in water to 100 mM
- Form / State: Solid
- Source: Synthetic
Overview
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Product name
Memantine hydrochloride, NMDA antagonist -
Description
NMDA antagonist, ion channel site -
Biological description
Antagonist at the NMDA receptor. Acts as a fast, voltage-dependent, open channel NMDA receptor blocker. Used in the clinic to treat Alzheimer's disease. Cognitive enhancer and anxiolytic in vivo.
Also available in simple stock solutions (ab146687) - add 1 ml of water to get an exact, ready-to-use concentration. -
Purity
> 98% -
CAS Number
41100-52-1 -
Chemical structure
Properties
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Chemical name
3,5-Dimethyl-1-adamantanamine hydrochloride -
Molecular weight
215.77 -
Molecular formula
C12H21N.HCl -
PubChem identifier
181458 -
Storage instructions
Store at Room Temperature. The product can be stored for up to 12 months. -
Solubility overview
Soluble in water to 100 mM -
Handling
Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.
Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.
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SMILES
Cl.CC13CC2(C)CC(N)(C1)CC(C2)C3 -
Source
Synthetic
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Research areas
Images
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Functional Studies - Memantine hydrochloride, NMDA antagonist (ab120249) Image from Wills TA et al., Proc Natl Acad Sci U S A. 2012;109(5):E278-87. Fig 6(D).; doi: 10.1073/pnas.1113820109.Averaged time courses of NMDA receptor-isolated synaptic field potentials in dorsal lateral bed nucleus of the stria terminalis following 60 minutes of memantine (5 or 30 μM; ab120249) in naive adult male C57BL/6J mice.
