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LY2940680 (Taladegib) (ab269874)

Key features and details

  • Potent Hedgehog signaling pathway inhibitor
  • CAS Number: 1258861-20-9
  • Soluble in DMSO to 100 mM with ultrasonic and warming
  • Form / State: Solid
  • Source: Synthetic

Overview

  • Product name

    LY2940680 (Taladegib)

  • Description

    Potent Hedgehog signaling pathway inhibitor

  • Alternative names

    • Taladegib

  • Biological description

    Potent Hedgehog signaling pathway inhibitor. Smoothened antagonist. Inhibits growth of cancer cell lines containing a disease-relevant Smoothened gene mutation. Has anti-tumor activity in animal models.

  • CAS Number

    1258861-20-9

  • Chemical structure

    Chemical Structure

Properties

  • Chemical name

    4-Fluoro-N-methyl-N-[1-[4-(1-methyl-1H-pyrazol-5-yl)-1-phthalazinyl]-4- piperidinyl]-2-(trifluoromethyl)benzamide

  • Molecular weight

    512.50

  • Molecular formula

    C26H24F4N6O

  • PubChem identifier

    49848070

  • Storage instructions

    Shipped at room temperature. Store at -20°C.

  • Solubility overview

    Soluble in DMSO to 100 mM with ultrasonic and warming

  • Handling

    Toxic, refer to SDS for further information.

    Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.

  • SMILES

    CN1C(=CC=N1)C2=NN=C(C3=CC=CC=C32)N4CCC(CC4)N(C)C(=O)C5=C(C=C(C=C5)F)C(F)(F)F

  • Source

    Synthetic

Images

  • Chemical Structure - LY2940680 (Taladegib) (ab269874)
    Chemical Structure - LY2940680 (Taladegib) (ab269874)

    Chemical structure of LY2940680 (Taladegib), 1258861-20-9

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