LY-333531 hydrochloride, protein kinase Cbeta inhibitor (ab219866)
Key features and details
- Potent, isozyme-selective protein kinase Cβ (PKCβ) inhibitor
- CAS Number: 169939-93-9
- Purity: > 98%
- Soluble in DMSO to 20 mM
- Form / State: Solid
- Source: Synthetic
Overview
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Product name
LY-333531 hydrochloride, protein kinase Cbeta inhibitor -
Description
Potent, isozyme-selective protein kinase Cβ (PKCβ) inhibitor -
Alternative names
- LY333531 hydrochloride
- Ruboxistaurin
- Ruboxistaurin hydrochloride
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Biological description
Potent, isozyme-selective inhibitor of protein kinase Cβ (PKCβ). Competitively inhibits PKCßI and PKCßII (IC50 values are 4.7 and 5.9 nM respectively). 76- and 61-fold selective for inhibition of PKCßI and PKCßII in comparison to PKCα, respectively. Exhibits selectivity for PKC over other ATP-dependent kinases, including protein kinase A, casein kinase and src).
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Purity
> 98% -
CAS Number
169939-93-9 -
Chemical structure
Properties
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Chemical name
(9S)-9-[(Dimethylamino)methyl]-6,7,10,11-tetrahydro-9H,18H-5,21:12,17-dimethenodibenzo[e,k]pyrrolo[3,4-h][1,4,13]oxadiazacyclohexadecine-18,20(19H)-dione hydrochloride -
Molecular weight
505.01 -
Molecular formula
C28H28N4O3.HCl -
PubChem identifier
9870785 -
Storage instructions
Shipped at 4°C. Store at -20°C. Store under desiccating conditions. -
Solubility overview
Soluble in DMSO to 20 mM -
Handling
Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.
Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.
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SMILES
CN(C)C[C@@H]1CCN2C=C(C3=CC=CC=C32)C4=C(C5=CN(CCO1)C6=CC=CC=C65)C(=O)NC4=O.Cl -
Source
Synthetic
