Luffariellolide, phospholipase A2 (PLA2) inhibitor. Agonist at RARalpha (ab141759)
Key features and details
- Potent phospholipase A2 (PLA2) inhibitor. Agonist at RARα
- CAS Number: 111149-87-2
- Purity: > 98%
- Soluble in DMSO and in ethanol
- Form / State: Solid
- Source: Luffariella sp.
Overview
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Product name
Luffariellolide, phospholipase A2 (PLA2) inhibitor. Agonist at RARalpha -
Description
Potent phospholipase A2 (PLA2) inhibitor. Agonist at RARα -
Biological description
Potent, partially reversible phospholipase A2 (PLA2) inhibitor (IC50 = 5 µM). Also a novel RARα agonist (EC50 = 1 μM). Derivative of marine sponge Luffariella sp. Displays anti-inflammatory activity and active in vivo. -
Purity
> 98% -
CAS Number
111149-87-2 -
Chemical structure
Properties
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Chemical name
3-[(3E,7E)-4,8-Dimethyl-10-(2,6,6-trimethylcyclohexen-1-yl)deca-3,7-dienyl]-2-hydroxy-2H-furan-5-one -
Molecular weight
386.57 -
Molecular formula
C25H38O3 -
PubChem identifier
5387248 -
Storage instructions
Store at -20°C. It is important to note that this product is reported to be light sensitive. Store In the Dark. Store under desiccating conditions. -
Solubility overview
Soluble in DMSO and in ethanol -
Handling
Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.
Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.
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SMILES
CC1=C(C(CCC1)(C)C)CCC(=CCCC(=CCCC2=CC(=O)OC2O)C)C -
Source
Luffariella sp.
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Research areas
